Tata Institute of Fundamental Research

Possible and Impossible Cells

STCS Colloquium
Speaker: Mukund Thattai (National Centre for Biological Sciences PO Bellary Road Vignana Kendra Bengaluru 560065)
Organiser: Piyush Srivastava
Date: Tuesday, 10 Oct 2017, 14:30 to 15:30
Venue: A-201 (STCS Seminar Room)

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Abstract:  We study the logistics system of eukaryotic cells, whose warehouses are micron-scale "organelles" and whose trucks are 10-nanometer-scale "vesicles". Organelles form the nodes and vesicle fluxes form the edges of a transport graph. Unlike traditional logistics systems, this graph is self-organized: vesicles are regulated by the very molecular cargo they carry, and organelle chemical identities arise as a balance of molecular gain and loss. We use rigorous graph theoretic approaches to delineate what kinds of transport graphs are impossible, and large-scale statistical methods to sample what kinds of graphs are likely. Living cells occupy the interesting space between these two boundaries.

For this talk, no biology background will be assumed from the audience!